Gonadorelin:

Gonadorelin, also called "gonadotropin releasing hormone" (GnRH), mirrors the natural neuropeptide produced by the hypothalamus in the brain. In healthy males, it is released in a pulsatile manner every two hours, prompting the anterior pituitary gland to release luteinizing hormone (LH), follicle stimulating hormone (FSH), and small amounts of human chorionic gonadotropin (HCG). These hormones stimulate the testicles to produce testosterone, estrogen, and sperm.

We prescribe gonadorelin to men undergoing testosterone replacement therapy (TRT) to prevent further testicular shrinkage and maintain testicular function. Men with severe testosterone deficiency often have reduced fertility and smaller testicular size. For older men, the focus is on preventing additional shrinkage, while younger men are concerned about preserving fertility and testosterone production.

Primarily, gonadorelin is prescribed for older men to delay or reverse testicular shrinkage exacerbated by TRT. This addresses physical symptoms like smaller testicles and reduced ejaculate, which can affect feelings of masculinity. Secondarily, it's prescribed for younger men aiming to maintain fertility and testosterone production during TRT, especially if they plan to have children in the future or are uncertain about continued TRT use.

Sermorelin:

What is Sermorelin?  

  • Sermorelin is a synthetic peptide that stimulates the secretion of growth hormone-releasing hormone (GHRH) from the hypothalamus, leading to increased production of growth hormone (GH) by the pituitary gland   

How Does Sermorelin Work? 

  • Sermorelin mimics the natural process of GHRH secretion in the body, promoting the release of growth hormone
  • By enhancing GH levels, Sermorelin contributes to various physiological processes, including tissue repair, metabolism, and muscle growth

Benefits of Sermorelin Therapy:

  • Improved Energy Levels: Sermorelin therapy can boost energy and vitality, combating fatigue and lethargy
  • Enhanced Muscle Growth: Increased GH levels support muscle protein synthesis, aiding in the development of lean muscle mass.   
  • Weight Loss Support: Sermorelin can help optimize metabolism and facilitate fat burning, contributing to weight loss efforts. 
  • Enhanced Recovery: Sermorelin promotes tissue repair and recovery, accelerating healing from injuries and workouts.   
  • Better Sleep Quality: Many individuals experience improved sleep patterns and quality with Sermorelin therapy, leading to overall well-being.   
  • Youthful Appearance: Sermorelin may help improve skin elasticity and reduce the appearance of wrinkles, promoting a more youthful complexion.   
  • Mental Clarity: Increased GH levels are associated with enhanced cognitive function and mental clarity, supporting overall brain health.   
  • Why Choose Sermorelin Therapy?
  • Safe and Natural: Sermorelin therapy stimulates the body's own production of growth hormone, offering a safe and natural approach to hormone optimization.   
  • Customized Treatment: Sermorelin therapy can be tailored to individual needs and goals, allowing for personalized treatment plans.   
  • Minimal Side Effects: Sermorelin therapy is generally well-tolerated, with minimal side effects reported compared to other hormone therapies.   
  • Long-Term Benefits: With consistent treatment, Sermorelin therapy can provide long-term benefits for vitality, wellness, and quality of life.  

Schedule a consultation today with a Precision Medical Provider to learn more about how Gonadorelin, Sermorelin, and other Peptides can benefit you.

References

1.    Mayo Clinic [Internet]. [place unknown]: IBM Watson Health; c 1998-2022. Gonadorelin (intravenous route, injection route); [updated 2022 Aug 1; cited 2022 Sep 7]. Available from: https://www.mayoclinic.org/drugs-supplements/gonadorelin-intravenous-route-injection-route/description/drg-20067426

2.    DrugBank Online [Internet]. [place unknown]: DrugBank Online. Gonadorelin; 2005 Jun 13 [updated 2022 Sep 6; cited 2022 Sep 7]. Available from: https://go.drugbank.com/drugs/DB00644

3.    Zhang L, Cai K, Wang Y, Ji W, Cheng Z, Chen G, Liao Z. The pulsatile gonadorelin pump induces earlier spermatogenesis than cyclical gonadotropin therapy in congenital hypogonadotropic hypogonadism men. Am J Mens Health [Internet]. 2019 Jan-Feb [cited 2022 Sep 7];13(1): Article 1557988318818280 [9 p.]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775549/. doi: 10.1177/1557988318818280

4.   [1] Kim KR, Nam SY, Song YD, Lim SK, Lee HC, Huh KB. Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults. Horm Res. 1999;51(2):78-84. doi: 10.1159/000023319. PMID: 10352397.;

5.   [2] Caicedo D, Díaz O, Devesa P, Devesa J. Growth Hormone (GH) and Cardiovascular System. Int J Mol Sci. 2018 Jan 18;19(1):290. doi: 10.3390/ijms19010290. PMID: 29346331; PMCID: PMC5796235.;

6.   [3] Tavares AB, Micmacher E, Biesek S, Assumpção R, Redorat R, Veloso U, Vaisman M, Farinatti PT, Conceição F. Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old. Int J Endocrinol. 2013;2013:942030. doi: 10.1155/2013/942030. Epub 2013 Dec 8. PMID: 24382963; PMCID: PMC3870652.;

7.   [4] Tavares AB, Micmacher E, Biesek S, Assumpção R, Redorat R, Veloso U, Vaisman M, Farinatti PT, Conceição F. Effects of Growth Hormone Administration on Muscle Strength in Men over 50 Years Old. Int J Endocrinol. 2013;2013:942030. doi: 10.1155/2013/942030. Epub 2013 Dec 8. PMID: 24382963; PMCID: PMC3870652.;

8.   [5] Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.;